Triptolide By Synthesis

Triptolide

                                      --- By Synthesis

    Triptolide, CAS: 38748-32-2, has been used in the treatment of many diseases, including lupus, tumor, rheumatoid arthritis, nephrotic syndrome, etc. In October 2012, researchers at the University of Minnesota found that the mouse model showed that the substance, a natural plant product with a long history of use in traditional Chinese medicine, was effective in the treatment of pancreatic cancer. Recent studies have shown that the substance has protective effects on cardiovascular diseases and osteoporosis. Various derivatives based on it as the core molecule are also widely favored by drug researchers.

       In nature, it is mainly found in the root bark, root heart and whole root of Tripterygium Wilfordii and the contents of it are 0.001%, 0.004% and 0.0018% respectively, which are extremely low. This greatly hinders the scope of application of it in medicine.

     There are many restrictive factors in obtaining it from nature. Therefore, relying on chemical synthesis technology, our company provides a solution for the industrial production of the substance, and realizes more than 20 steps of all-chemical synthesis process, meeting the kilogram-level volume requirement, which will greatly reduce the production cost of it in the future and solve the bottleneck of industrial mass production.

    The quality standard of Triptolide is benchmarked against natural products, and indicators such as chirality and content have reached the target requirements. At the same time, our company has also completed relevant quality research work, and relevant impurities have also been stored. We can quickly respond to the research, declaration, production and other work of pharmaceutical factories.